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| Product Name: |
10-hydroxycamptothecin
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| Supply Ability: |
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| Related proudcts |
medicine, 10-hydroxycamptothec, camptothecine, |
| Specifications |
10-hydroxycamptothecin |
| Price Term: |
we can negotate |
| Port of loading: |
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| Minimum Order |
10KG |
| Unit Price: |
we can negotate |
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10-hydroxycamptothecin is an alkaloid derived from the chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Product Information
CAS Number: 7689-03-4
Origin: Camptotheca acuminate
Molecular Structure:
Molecular Formula: C20H16N2O4
Molecular Weight: 348.36
Appearance: Light Yellow Crystal
Purity by HPLC: 98% min / 99% min
Solubility: Clear Yellow Solution at 1Mg/Ml in Dimethylsulfoxide
Packing: Nt.W:1kg/bag
Storage: Store in a cool and dry area. Keep sealed and keep away from direct light.
Sichuan MaoYuan Biochemical Technology Co., Ltd.
Duba
Email:duba2010@ho***il.com
MSN: duba2010@ho***il.com
MB: (0086)18782225059
Website:www.maoyuanbio.com
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| Company: |
Sichuan MaoYuan Biochemical Technology Co., Ltd.
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| Contact: |
Mr. Du ba |
| Address: |
#99 yingchanggou south RD,sichuan,china |
| Postcode: |
620000 |
| Tel: |
86-28-88504192 |
| Fax: |
86-28-88504192 |
| E-mail: |
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